By Ahcene Boumendjel, Jean Boutonnat, Jacques Robert

ISBN-10: 0470227346

ISBN-13: 9780470227343

A complete evaluation of the most up-tp-date clinical study on ABC transporters and multidrug resistanceATP-binding cassette transporter genes (ABC transporters) are recognized to play a vital position within the improvement of multidrug resistance (MDR). MDR is the power of pathologic cells, resembling tumors, to resist chemical compounds designed to focus on and ruin such cells. In MDR, sufferers who're on medicine ultimately enhance resistance not to simply the drug they're taking, yet to a number of forms of drugs.ABC Transporters and Multidrug Resistance bargains an important source for pharmaceutical researchers who're operating to find medications to counteract multidrug resistance in illnesses reminiscent of melanoma. in a single accomplished quantity, this booklet incorporates a number of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.This finished quantity offers an summary at the description of the constitution, the genome, general tissue expression, physiological element, and mechanism of motion of the ABC protein. The specialist individuals discover the expression, detection, and implications of ABC proteins in hematological malignancies and stable tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. moreover, the booklet deals crucial info at the organic and medical point of multidrug resistance.

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ABC Transporters and Multidrug Resistance (Wiley Series in Drug Discovery and Development) by Ahcene Boumendjel, Jean Boutonnat, Jacques Robert


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